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Everything about NG 52
Investigations into the mechanisms of motion have revealed that TAK-242 binds selectively to Cys747 during the TIR area of TLR4 [23] and subsequently disrupts the flexibility of TLR4 to affiliate with TIRAP [24]. So far, TAK-242 is the one modest-molecule compound claimed to manage protein–protein interactions among TLR4 and its adaptor molecules